Palmoplantar erythrodysesthesia syndrome is a relatively common syndrome induced by many chemotherapeutic agents, most frequently 5-fluouracil (5-FU),doxorubicin, and cytosine arabinoside. The reaction which is dose-dependent may occur in as many as 40% of treated patients.

The current case is a 62-year-old man with chronic lymphocytic leukemia who few days after starting chemotherapy  complained of dysesthesia of the palms which in a few days followed by painful, symmetric dusky erythema and edema of the palms and less severe reaction on the dorsal surface of both hands.