A 25-year-old lady presented with burning, well-circumscribed, red scaly rash with fine fissures involved the chin of 5 days duration. The patient gave history of applying a topical cream containing Tretinoin + Hydroquinone + Mometasone, two days after she developed this rash. Tretinoin was the most suspected culprit. Stopping this topical preparation and twice daily application of Betamethasone valerate ointment gave dramatic improvement.