A very interesting case with typical iris-like lesions involved the extensor surface of both forearms and wrist areas of 10 days duration in a 20-year-old female. She had no previous history of drug intake or preceding systemic or cutaneous infection.

          An 38-year-old lady presented in a bad general state, dehydrated, febrile and severe bullous reaction of three days duration after one intramuscular injection of an antibiotic (Cefotaxime?). She had severe mucous membrane involvement with swelling and denudation (mouth, conjunctivae and vagina) in addition to severe blistering of the skin with many target lesions.

           A 12-year-girl presented with a large pruritic solitary classical wheal with few smaller ones confined to the dorsum of one hand. Fish has been suspected as the causative culprit.

          A young adult man presented with a few days history of severely pruritic, evanescent geographical map-like wheals, some of which had an annular configuration involved most parts of the body but especially the trunk. There was no recognizable precipitating factor.

         A 65-year-old woman with long history of osteoarthritis has taken recently a new NSAID. One day later she developed a severe blistering rash involved the entire integument in addition to many mucosal orifices (oral, nasal and conjunctival). On admission to the hospital, she was in a bad general condition with impending hypovolemic shock.

          A 60-year-old woman presented with severe drug-induced reaction on both lower limbs with few lesions elsewhere in addition to mucosal involvement of the mouth of two days duration. The insulting drug was sulfonamide and the onset of the rash was within 48 hours of taking the drug. The rash comprised of bilateral symmetrical bullae on a background of erythematous macules and patches in addition to erosions and peeling.